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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CBL All Species: 4.55
Human Site: S606 Identified Species: 9.09
UniProt: P22681 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0.09
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P22681 NP_005179.2 906 99633 S606 P V S A P S S S D P W T G R E
Chimpanzee Pan troglodytes XP_508878 860 94390 P562 S A P S S S D P W T G R E L T
Rhesus Macaque Macaca mulatta XP_001104812 907 99834 S607 P V S A P S S S D P W T G R E
Dog Lupus familis XP_546487 769 85337 D490 G T E P I V V D P F D P R G S
Cat Felis silvestris
Mouse Mus musculus P22682 913 100531 G604 P V A T P N P G D P W N G R E
Rat Rattus norvegicus Q8K4S7 938 104634 P616 L G D G S P K P G V T A N S N
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001520299 576 65568 R297 Q A L I D G F R E G F Y L F P
Chicken Gallus gallus NP_989539 903 99806 G590 P S V A H S P G D H W P G R E
Frog Xenopus laevis Q6GQL0 918 102813 L626 T H D G S P K L G V P S S S V
Zebra Danio Brachydanio rerio NP_001007331 913 101156 D594 S Q P P A S G D T R G S R E L
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_648224 878 94769 G592 C V A N S T Y G Q K L P Q N C
Honey Bee Apis mellifera XP_395448 739 83094 H460 I M D L C N G H C G L M C Y D
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 94.9 98.9 70 N.A. 92.7 49.5 N.A. 52.3 84 49.6 72.2 N.A. 41.6 44.5 N.A. N.A.
Protein Similarity: 100 94.9 99.2 72 N.A. 95 60.8 N.A. 57.6 89.4 59 80.2 N.A. 53.6 56.9 N.A. N.A.
P-Site Identity: 100 6.6 100 0 N.A. 60 0 N.A. 0 53.3 0 6.6 N.A. 6.6 0 N.A. N.A.
P-Site Similarity: 100 13.3 100 0 N.A. 73.3 0 N.A. 13.3 53.3 6.6 13.3 N.A. 20 20 N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 17 17 25 9 0 0 0 0 0 0 9 0 0 0 % A
% Cys: 9 0 0 0 9 0 0 0 9 0 0 0 9 0 9 % C
% Asp: 0 0 25 0 9 0 9 17 34 0 9 0 0 0 9 % D
% Glu: 0 0 9 0 0 0 0 0 9 0 0 0 9 9 34 % E
% Phe: 0 0 0 0 0 0 9 0 0 9 9 0 0 9 0 % F
% Gly: 9 9 0 17 0 9 17 25 17 17 17 0 34 9 0 % G
% His: 0 9 0 0 9 0 0 9 0 9 0 0 0 0 0 % H
% Ile: 9 0 0 9 9 0 0 0 0 0 0 0 0 0 0 % I
% Lys: 0 0 0 0 0 0 17 0 0 9 0 0 0 0 0 % K
% Leu: 9 0 9 9 0 0 0 9 0 0 17 0 9 9 9 % L
% Met: 0 9 0 0 0 0 0 0 0 0 0 9 0 0 0 % M
% Asn: 0 0 0 9 0 17 0 0 0 0 0 9 9 9 9 % N
% Pro: 34 0 17 17 25 17 17 17 9 25 9 25 0 0 9 % P
% Gln: 9 9 0 0 0 0 0 0 9 0 0 0 9 0 0 % Q
% Arg: 0 0 0 0 0 0 0 9 0 9 0 9 17 34 0 % R
% Ser: 17 9 17 9 34 42 17 17 0 0 0 17 9 17 9 % S
% Thr: 9 9 0 9 0 9 0 0 9 9 9 17 0 0 9 % T
% Val: 0 34 9 0 0 9 9 0 0 17 0 0 0 0 9 % V
% Trp: 0 0 0 0 0 0 0 0 9 0 34 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 9 0 0 0 0 9 0 9 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _